Amy Regish

2001: M.S. University of Massachusetts, Amherst (Aquatic Toxicology) 
1988: B.S. University of Vermont, Burlington (Animal Sciences)

Research Interests: 
I am broadly interested in the physiologic response of anadromous fish species to natural and anthropogenic alterations of aquatic ecosystems. Some of the many challenges faced by anadromous fish species are from warming temperatures due to climate change, manmade impediments to migration, and contaminant exposure. The impact of these perturbations on thermal tolerance, stress physiology, and osmoregulation is of particular concern in the conservation and restoration efforts directed towards anadromous fish species in the Northeast. Research to help develop an understanding the physiological responses will help in these efforts.


Carey, M.P., Keith, K.D., Schelske, M., Lean, C., McCormick, S.D., Regish, A., and Zimmerman, C.E. 2019. Energy depletion and stress levels of Sockeye Salmon migrating at the northern edge of their distribution. Transactions of the American Fisheries Society (in press)


McCormick, S.D., Regish, A.M., Ardren, W.R., Björnsson, B.Th. and Bernier, N.J. 2019. The evolutionary consequences for seawater performance and its hormonal control when anadromous Atlantic salmon become landlocked. Scientific Reports 9:968

McCormick, S.D. and Regish, A.M. 2018. Effects of ocean acidification on salinity tolerance and seawater growth of Atlantic salmon Salmo salar smolts. Journal of Fish Biology 93: 560-566

Vargas-Chacoff, L., Regish, A.M., Weinstock, A. and McCormick, S.D. 2018. Effects of elevated temperature on osmoregulation and stress responses in Atlantic salmon Salmo salar smolts in fresh water and seawater. Journal of Fish Biology 93: 550-559

Regish, A.M, Kelly, J.T., O'Dea, M.F., and McCormick, S.D. 2018. Sensitivity of Na+/K+-ATPase isoforms to acid and aluminum explains differential effects on Atlantic salmon osmoregulation in fresh water and seawater. Canadian Journal of Fisheries and Aquatic Sciences 75: 1319-1328

Christensen, A.K., Regish, A.M. and McCormick, S. D. 2018. Shifts in the relationship between mRNA and protein abundance of gill ion transporters during smolt development and seawater acclimation in Atlantic salmon (Salmo salar). Comparative Biochemistry and Physiology Part A 221: 63-73


Bayse, S.M., Regish, A.M. and McCormick, S. D. 2018. Proximate composition, lipid utilization and validation of a non-lethal method to determine lipid content in migrating American shad Alosa sapidissima. Journal of Fish Biology 92: 1832–1848

Zak, M.A., Regish, A.M., McCormick, S.D., and Manson, R.G. 2017. Exogenous thyroid hormones regulate the activity of citrate synthase and cytochrome c oxidase in warm- but not cold-acclimated lake whitefish (Coregonus clupeaformis). General and Comparative Endocrinology 247: 215-222

Breves, J.P., Phipps-Costin, S.K., Fujimoto, C.K., Einarsdottir, I.E., Regish, A.M., Björnsson, B.Th. and McCormick, S.D. 2016. Hepatic insulin-like growth-factor binding protein (igfbp) responses to food restriction in Atlantic salmon smolts. General and Comparative Endocrinology 233: 79-87.

Kelly, J.T., Lerner, D. T., O’Dea, M. F., Regish, A. M., Monette, M.Y., Hawkes, J.P., Nislow, K.H. and McCormick, S.D. 2015. Evidence for episodic acidification impacts on migrating Atlantic salmon smolts in the United States. Journal of Fish Biology 87: 1129-1146.

McCormick, S.D., Haro, A., Lerner, D.T., O’Dea, M.F., and Regish, A.M. (2014). Migratory patterns of hatchery and stream-reared Atlantic salmon Salmo salar smolts in the Connecticut River, U.S.A. Journal of Fish Biology. 

McCormick, S.D., Regish, A.M. and Christensen, A.K. 2009. Distinct freshwater and seawater isoforms of Na+/K+-ATPase in gill chloride cells of Atlantic salmon. Journal of Experimental Biology 212: 3994-4001. 

McCormick, S.D., Regish, A.M., O'Dea, M.F. and Shrimpton, J.M. 2008. Are we missing a mineralocorticoid in teleost fish? Effects of cortisol, deoxycorticosterone and aldosterone on osmoregulation, gill Na+/K+-ATPase activity and isoform mRNA levels in Atlantic salmon. General and Comparative Endocrinology 157: 35-40.

McCormick, S.D., O'Dea, M.F., Moeckel, A.M., Lerner, D.T. and Björnsson, B.Th. 2005. Endocrine disruption of parr-smolt transformation and seawater tolerance of Atlantic salmon by 4-nonylphenol and 17β-estradiol. General and Comparative Endocrinology 142: 280-288

McCormick, S.D., O'Dea, M.F., Moeckel, A.M., Björnsson, B.Th. 2003. Endocrine and physiological changes in Atlantic salmon smolts following hatchery release. Aquaculture 222: 45-57

Campbell, J.S., Seger, R., Jensen, A.M., and Krebs, E.G. The Map Kinase Cascade. Recent Progress in Hormone Research. Vol. 50, pp. 131-159, 1995.

Ahn, N.G., Campbell, J.S., Seger, R., Jensen, A.M., Graves, L.M., and Krebs, E.G.. Metabolic Labeling of Mitogen Activated Protein Kinase Kinase in A431 Cells Demonstrates Phosphorylation on Serine and Threonine Residues.  Proc. Natl. Acad. Sci. Vol. 90, pp. 5143-5147, June 1993.

Seger, R., Ahn, N.G., Posada, J., Munar, E.S.,Jensen, A.M.,Cooper, J.,Cobb, M.H., and Krebs, E.G..  Purification and Characterization of Mitogen Activated Protein Kinase Activators from Epidermal Growth Factor Stimulated A431 Cells. The Journal of Biological Chemistry. Vol. 267(20), pp. 14373-14381, July 15, 1992.

Seger, R., Seger, D., Lozeman, F.J., Ahn, N.G., Graves, L.M., Campbell, J.S., Ericsson, L., Harrylock, M., Jensen, A.M., and Krebs, E.G. Human T-Cell Mitogen Activated Protein Kinase Kinases are Related to Yeast Signal Transduction Kinases. The Journal of Biological Chemistry. Vol. 267(36), pp. 25628-25631, Dec 25, 1992.

Farrington, G.K., Lynch, P.,Jensen, A., Bonhlein, E., Doten, V, Maione, T., Daly, T., and Rusche, J. The Lentivirus Regulatory Proteins REV and REX are Site Specific RNA Binding Proteins. Adv. Exp. Med. Biol. Vol. 303, pp. 15-22, 1991